Transgene in Collaboration with Emergent BioSolutions to Receive NIH Funding to Support Development of a Novel Immunotherapy against Tuberculosis
Strasbourg, France, October 30, 2013 - Transgene SA (NYSE-Euronext: TNG) announced today that it has been granted a sub-award from Emergent BioSolutions Inc. (NYSE:EBS) under its existing grant of approximately $5 million from the U.S. National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health (NIH)1. The funding will be used to advance Transgene's tuberculosis (TB) immunotherapy program.
program is focused on developing a targeted immunotherapeutic to
treat active TB, including resistant TB, utilizing the Company's
core viral vector technology. These novel immunotherapeutics
contain, among other elements, a large array of TB proteins expressed
during all phases of both active and latent infection. An
immunotherapy approach offers the potential, especially for patients
whose disease has become resistant to treatment, to enhance the
effectiveness of current antibacterial therapies by correcting the
immune system's faulty response to the disease. Several potential
product candidates have been generated by Transgene and are currently
being evaluated to determine the best candidate to advance into
Transgene has entered into a collaboration with Emergent BioSolutions for cell line process development and manufacturing for Transgene's TB development candidate. Emergent BioSolutions' significant expertise in process development and manufacturing complements Transgene's capabilities.
Transgene retains all
development and commercialization rights to candidates generated
under this NIAID-funded program.
“There is an
urgent need for new treatments for tuberculosis, which remains an
acute problem in emerging countries and is rapidly reappearing in
parts of the developed world, notably Europe. The NIAID funding, as
well as the collaboration with Emergent BioSolutions, should
accelerate Transgene's TB immunotherapy development program, which
seeks to help address this major medical need,” said Philippe
Archinard, Chairman and Chief Executive Officer of Transgene. He
added: “Our TB program, a unique, truly innovative antigenic
combination, is a good example of the adaptability of Transgene's
viral vector-based immunotherapy core technology and the productivity
of our R&D engine.”
About Tuberculosis (TB):
TB is an infectious disease that primarily affects the lungs and can be lethal if left untreated or when resistance is developed. TB remains one of the deadliest infectious diseases in the world. According to WHO (World Health Organization), in 2011, there were an estimated 8.7 million new cases of TB and 1.4 million people died from the disease. A major issue of TB infection is the development of resistance to primary antibiotic treatment. Such cases amount to approximately 500,000 cases worldwide. The success rate of second-line therapy to treat patients whose disease has become resistant to treatment varies widely, from 15-60% depending on the degree of resistance, and requires 18-30 months of application.
There is currently
only one available TB vaccine, Bacille Calmette-Guérin (BCG),
developed in 1921, which is widely used and effective in preventing
severe forms of TB in children. However, BCG has little to no
efficacy in preventing pulmonary TB, the most common and infectious
form of TB in adults and adolescents, and is unsafe to use in
newborns with HIV.
immunotherapies are needed for those populations for whom there is
today no effective treatment, as well as to overcome resistance and
to shorten treatment duration.
About Transgene SA
Transgene, a member of the Institut Mérieux Group, is a publicly traded French biopharmaceutical company focused on discovering, developing and manufacturing targeted immunotherapies for the treatment of cancer and infectious diseases. Transgene's programs utilize well-tolerated viruses with the goal of indirectly or directly killing infected or cancerous cells. The Company's four clinical-stage programs are: TG4010 for non-small cell lung cancer; Pexa-Vec for liver cancer; TG4001 for oropharyngeal cancer (under a collaboration agreement with the EORTC) and TG4040 for chronic Hepatitis C. Transgene has concluded corporate strategic agreements for the development of two of its immunotherapy products: an exclusive option agreement with Novartis for the development and commercialization of TG4010 and an in-licensing agreement with US-based Jennerex, Inc. for the development and commercialization of Pexa-Vec in certain territories. The Company also has several programs in research and pre-clinical development that are based on its core viral vector technology. Transgene is based in Strasbourg, France, and has additional operations in Lyon, as well as satellite offices in China and the U.S. Additional information about Transgene is available at www.transgene.fr.
Transgene Forward-Looking Statements
This press release contains forward-looking statements. Such statements are based on the current plan of product development and testing. This plan may change in the future and, as such, Transgene may not meet currently anticipated development milestones. For further information on the risks and uncertainties involved in the testing and development of Transgene's product candidates, see Transgene's Document de Référence on file with the French Autorité des marchés financiers on its website at http://www.amffrance.org and on Transgene's website at www.transgene.fr.
Philippe Archinard, Chairman & Chief Executive Officer, +33 (0)3 88 27 91 22
Stéphane Boissel, Executive Vice President & CFO, +33 (0)3 88 27 91 02
Elisabetta Castelli, Director Investor Relations, +33 (0)3 88 27 91 21
Raimund Gabriel, +49 89 210 228 30
Shaun Brown, +44 207 148 5998
1 The project described is supported by award number R01AI098911 from the National Institutes of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH). Transgene is solely responsible for the content of this release, which does not necessarily represent the official view of the NIH.
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